Vardenafil é o medicamento mais recente para o tratamento da disfunção erétil
História da criação do medicamento Vardenafil (substância ativa de Levitra)
Vardenafil é a substância ativa do medicamento com a marca Levitra que é usado para tratar a disfunção eréctil. Esta substância ativa foi desenvolvida por três empresas farmacêuticas: Bayer Pharmaceuticals, GlaxoSmithKline e Schering-Plough, mas os direitos da marca Levitra pertencem a Bayer Pharmaceuticals.
Vardenafil é o medicamento mais recente para o tratamento da disfunção erétil, uma vez que foi oficialmente aprovado pela FDA apenas em 2007 e imediatamente entrou no mercado farmacêutico.
Vardenafil (Levitra) não é a única substancia ativa mas este medicamento tem características próprias que o tornam preferível para muitos homens.
As principais características terapêuticas do Vardenafil (Levitra):
- Início rápido do efeito farmacológico – 15 minutos após tomar o comprimido
- Ausência de efeitos colaterais para o sistema cardiovascular
- Boa tolerância em homens com idade mais avançada
- Pode ser tomado junto com alimentos
- Dose única baixa
O mecanismo de ação de Vardenafil é o mesma que o dos seus análogos: ele aumenta o fluxo sanguíneo no pénis do homem, o que leva a que durante a excitação sexual o pénis se encha melhor e mais rápido com sangue e tenha uma ereção.
Phototherapy Promotes Healing of Chronic Diabetic Leg Ulcers That Failed to Respond to Other Therapies
Lasers in Surgery and Medicine 41:433–441
Debora G. Minatel, PT, PhD,1,2 Marco Andrey C. Frade, MD, PhD,3 Suzelei C. Franc¸a, PhD,1 and Chukuka S. Enwemeka, PhD, FACSM (2009)
Objective: We tested the hypothesis that combined 660 and 890nm LED phototherapy will promote healing of diabetic ulcers that failed to respond to other forms of treatment.
Research Design and Methods: A double-blind randomized placebo controlled design was used to study 23 diabetic leg ulcers in two groups of 14 patients. Group one ulcers were cleaned, dressed with 1% silver sulfadiazine cream and treated with ‘‘placebo’’ phototherapy (<1.0Jcm2) twice per week, using a Dynatron Solaris 7051 device. Group two ulcers were treated similarly but received 3Jcm2 dose.
Results: At each of 15, 30, 45, 60, 75, and 90 days of healing, mean ulcer granulation and healing rates were signiﬁcantly higher for group two than the ‘‘placebo’’ group (P<0.02). While ‘‘placebo’’ treated ulcers worsened during the initial 30 days, group two ulcers healed rapidly; achieving 56% more granulation and 79.2% faster healing by day 30, and maintaining similarly higher rates of granulation and healing over the ‘‘placebo’’ group all through. By day 90, 58.3% of group two ulcers had healed fully and 75% had achieved 90–100% healing. In contrast, only one ‘‘placebo’’ treated ulcer healed fully by day 90; no other ulcer attained90% healing.
Conclusion: Combined 660 and 890nm light promotes rapid granulation and healing of diabetic ulcers that failed to respond to other forms of treatment.
What is this medicine?
VARDENAFIL is used to treat erection problems in men. Vardenafil works faster than Sildenafil (Viagra®) and it is less likely to have visual disturbance side effect.
What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:
anatomical deformity of the penis, Peyronie’s disease, or ever had an erection that lasted more than 4 hours
frequent heartburn or gastroesophageal reflux disease (GERD)
heart disease, angina, high or low blood pressure, a history of heart attack, or other heart problems
sickle cell disease
stomach or intestinal ulcers
eye or vision problems
an unusual reaction to vardenafil, medicines, foods, dyes, or preservatives
How should this medicine be used?
Take vardenafil tablets by mouth with or without food. The dose is usually taken about 1 hour before sexual activity. Swallow the tablets with a drink of water. Do not take double or extra doses.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
What if I miss a dose?
This does not apply. However, do not take double or extra doses.
What may interact with this medicine?
Do not take vardenafil if you are taking the following medications:
nitroglycerin-type drugs for the heart or chest pain such as amyl nitrite, isosorbide dinitrate, isosorbide mononitrate, nitroglycerin, even if these are only taken occasionally. This includes some recreational drugs called ‘poppers’ which also contain amyl nitrate and butyl nitrate.
Vardenafil may also interact with the following medications:
alpha blockers such as alfuzosin (UroXatral®), doxazosin (Cardura®), prazosin (Minipress®), tamsulosin (Flomax®), or terazosin (Hytrin®), used to treat high blood pressure or an enlarged prostate.
certain antibiotics such as clarithromycin, erythromycin, sparfloxacin, troleandomycin
certain medicines used for seizures such as carbamazepine, phenytoin, and phenobarbital
certain medicines for the treatment of HIV infection or AIDS
certain medicines to control the heart rhythm (e.g. amiodarone, disopyramide, dofetilide, flecainide, ibutilide, quinidine, procainamide, propafenone, sotalol)
medicines for fungal infections (fluconazole, itraconazole, ketoconazole, voriconazole)
rifabutin, rifampin, or rifapentine
some medicines for treating depression or mood problems (amoxapine, maprotiline, fluoxetine, fluvoxamine, nefazodone, pimozide, phenothiazines, tricyclic antidepressants)
Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.
What should I watch for while taking this medicine?
If you notice any changes in your vision while taking this drug, notify your prescriber or health care professional as soon as possible. Stop using vardenafil right away if you have a loss of sight in one or both eyes. Contact your healthcare provider immediately.
Contact your physician immediately if the erection lasts longer than 4 hours or if it becomes painful. This may be a sign of priapism and must be treated immediately to prevent permanent damage.
If you experience symptoms of nausea, dizziness, chest pain or arm pain upon initiation of sexual activity after vardenafil use, you should refrain from further activity and should discuss the episode with your prescriber or health care professional as soon as possible.
Do not change the dose of your medication. Please call your prescriber or health care professional to determine if your dose needs to be reevaluated.
Using vardenafil does not protect you or your partner against HIV infection (the virus that causes AIDS) or other sexually transmitted diseases.
What side effects may I notice from this medicine?
Side effects that you should report to your prescriber or health care professional as soon as possible.
changes in hearing such as loss of hearing or ringing in ears
changes in vision such as loss of vision, blurred vision, eyes being more sensitive to light, or trouble telling the difference between blue and green objects or objects having a blue color tinge to them
chest pain or palpitations
difficulty breathing, shortness of breath
prolonged erection (lasting longer than 4 hours)
skin rash, itching
Side effects that usually do not require medical attention (report to your prescriber or health care professional if they continue or are bothersome):
This list may not describe all possible side effects.
Where can I keep my medicine?
Keep out of the reach of children.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.
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